2-(3-Ethoxy-5-ethyl-2-fluorophenyl)-2-hydroxyacetonitrile → 2-(5-Ethyl-2-fluoro-3-methoxyphenyl)-2-hydroxyacetonitrile

HRID 1438162노트

반응식

HRID 1438162 반응식
C(C1C=C(OC)C(F)=C(C=1)C=O)C.[CH2:14]([O:16][C:17]1[C:18]([F:29])=[C:19]([CH:25]([OH:28])[C:26]#[N:27])[CH:20]=[C:21]([CH2:23][CH3:24])[CH:22]=1)C>>[CH2:23]([C:21]1[CH:22]=[C:17]([O:16][CH3:14])[C:18]([F:29])=[C:19]([CH:25]([OH:28])[C:26]#[N:27])[CH:20]=1)[CH3:24]

참가 물질

3

반응물 2

HCID 579428002-(3-Ethoxy-5-ethyl-2-fluorophenyl)-2-hydroxyacetonitrileHCID 598380485-Ethyl-2-fluoro-3-methoxybenzaldehyde

생성물 1

HCID 598380052-(5-Ethyl-2-fluoro-3-methoxyphenyl)-2-hydroxyacetonitrile

실험 절차

119B was prepared from 119A using a procedure similar to that used in the preparation of 118E. 1H NMR (400 MHz, CDCl3) δ ppm 1.23 (t, J=7.47 Hz, 3H) 2.64 (q, J=7.62 Hz, 2H) 3.89 (s, 3H) 5.76 (s, 1H) 6.86 (dd, J=7.91, 2.20 Hz, 1H) 6.98 (dd, J=5.93, 1.98 Hz, 1H).

출처 및 근거

ORD 기록
ord-99bd70eb62ba42deaace1ff199e1c0b3
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622585B2

반응 노트

불러오는 중…