Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Cyanide → 2-(3-Difluoromethoxyphenyl)-2-hydroxyacetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | 3-(Difluoromethoxy)benzaldehyde | HCID 2736985 | — |
| 반응물 | Sodium Bisulfite | HCID 23665763 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-(3-Difluoromethoxyphenyl)-2-hydroxyacetonitrile | HCID 54493847 | 92.9% |
반응 단계
To 3-difluoromethoxybenzaldehyde (1.77 g, 10 mmol) in ethyl acetate (25 mL) was added a solution of KCN (2.0 g) and NaHSO3 (3.2 g) dissolved in H2O (25 mL). It was left stirring overnight before it was extracted with ethyl acetate (2×50 mL). The combined organic extracts were dried and concentrated. The crude product was purified by silica gel chromatography to give 131A (1.85 g, 92% yield) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07622585B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-6d746ab88683482984bcbc8e121a4e74 |
| 출처 메모 | uspto-grants-2009_11 |