2,2,2-Trifluoro-1-(2-methoxyphenyl)ethanone → 2,2,2-Trifluoro-1-(2-methoxyphenyl)ethanol
반응식
[F:1][C:2]([F:14])([F:13])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH3:12])=[O:4]>[Pd].CO>[F:1][C:2]([F:13])([F:14])[CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH3:12])[OH:4]참가 물질
4
실험 절차
10% Palladium on carbon (1.5 g) was added to a solution of 2,2,2-trifluoro-1-(2-methoxyphenyl)ethanone (3.0 g) in methanol (50 ml). The resultant was hydrogenated at room temperature for 12 hrs. After which time the catalyst was filtered off through a plug of celite and the solvent concentrated in vacuuo. The crude was purified by column chromatography on silica gel eluting with 100% hexanes the 80:20 hexanes:ethylacetate to afford the title compound as a yellow oil (3.0 g). 1H NMR (CDCl3): δ 3.75 (d, J=2.56 Hz, 1H), 3.96 (s, 3H), 5.35 (m, 1H), 7.05 (m, 2H), 7.50 (m,2H).
후처리
- filtrationAfter which time the catalyst was filtered off through a plug of celite
- concentrationthe solvent concentrated in vacuuo
- customThe crude was purified by column chromatography on silica gel eluting with 100% hexanes the 80:20 hexanes
출처 및 근거
- ORD 기록
- ord-72b13c5fbe104c35963357ec90e9e087
- 출처 데이터셋
- uspto-grants-2009_11
- 특허 번호
- US07622605B2
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