Piperidine → 6-tert-Butyl-2-piperidin-1-ylnicotinonitrile

반응식

[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7](Cl)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

반응물 2

HCID 8082Piperidine

HCID 532788766-Tert-butyl-2-chloropyridine-3-carbonitrile

생성물 1

HCID 588735266-tert-Butyl-2-piperidin-1-ylnicotinonitrile수율 98%

실험 절차

A mixture of 6-tert-butyl-2-chloronicotinonitrile (Tetrahedron 1965, 21, 2453-2467, 1.5 g, 7.7 mmol) and piperidine (15 ml, 176 mmol) was stirred for 20 hours at room temperature. Then the reaction mixture was evaporated to remove piperidine in vacuo to give the title compound (1.8 g, 98%).

후처리

customThen the reaction mixture was evaporated
customto remove piperidine in vacuo

출처 및 근거

ORD 기록: ord-80d446bf3b074083b1f562d054f90ae1
출처 데이터셋: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07622589B2

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