Acetic Acid → HCID 21400228, 화합물

HRID 1438700노트

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HRID 1438700 반응식
[CH3:1][N:2]1[C:7](=[O:8])[NH:6][CH:5](SC)[N:4]([NH2:11])[C:3]1=[O:12].C(O)(=O)C.[CH3:17][NH2:18]>C(O)(C)C>[CH3:1][N:2]1[C:7](=[O:8])[NH:6][CH:5]([NH:18][CH3:17])[N:4]([NH2:11])[C:3]1=[O:12]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 6329MethylamineHCID 53642864HCID 53642864, 화합물

생성물 1

HCID 21400228HCID 21400228, 화합물수율 88%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

18.8 g (0.1 mole) of 1-methyl-3-amino-4-methylmercaptotetrahydro-1,3,5-triazine-2,6-dione (prepared according to Example 2) were idssolved in 200 ml of isopropanol with addition of 6 g of glacial acetic acid and a pinch of ptoluenesulphonic acid and the mixture was saturated with methylamine gas at room temperature. The batch was left to stand for about 10 hours and was evaporated in vacuo, and the resudue was recrystallized from isopropanol. 15 g (88%) of 1-methyl-3-amino-4-methylamino-tetrahydro-1,3,5-triazine2,6-dione were obtained as a colorless powder; melting point 225°-227° C.

후처리

  1. waitThe batch was left
  2. customwas evaporated in vacuo
  3. customthe resudue was recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-9033d03f3b2b4826a01a60825f5c1b9d
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04056527

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