Hydrogen Peroxide → 1,1-Dimethyl-3-(4-cyano-3-(methylsulfinyl)-5-isothiazolyl)urea

반응식

[CH3:1][N:2]([CH3:15])[C:3]([NH:5][C:6]1[S:10][N:9]=[C:8]([S:11][CH3:12])[C:7]=1[C:13]#[N:14])=[O:4].[OH:16]O>>[CH3:15][N:2]([CH3:1])[C:3]([NH:5][C:6]1[S:10][N:9]=[C:8]([S:11]([CH3:12])=[O:16])[C:7]=1[C:13]#[N:14])=[O:4]

참가 물질

반응물 2

HCID 784Hydrogen Peroxide

HCID 213992751,1-Dimethyl-3-(4-cyano-3-(methylthio)-5-isothiazolyl)urea

생성물 1

HCID 213992851,1-Dimethyl-3-(4-cyano-3-(methylsulfinyl)-5-isothiazolyl)urea

실험 절차

In the manner of Example II, 7.9 g of 1,1-dimethyl-3-(4-cyano-3-(methylthio)-5-isothiazolyl)urea was oxidized with 3.7 ml of 30% hydrogen peroxide to give 7.0 g of 1,1-dimethyl-3-(4-cyano-3-(methylsulfinyl)-5-isothiazolyl)urea, m.p. 178°-179°. The nmr spectrum was consistent with the assigned structure.

출처 및 근거

ORD 기록: ord-379b7ec6410f4832a35d1853baaad2bc
출처 데이터셋: uspto-grants-1977_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04057416

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