Sodium Bicarbonate → 2-(3-Acetyl-4-hydroxyphenyl)propan-1-ol

HRID 1438980

반응식

HRID 1438980 반응식
C([O:4][CH2:5][CH:6]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([C:15](=[O:17])[CH3:16])[CH:9]=1)[CH3:7])(=O)C.C(=O)(O)[O-].[Na+]>C(O)C.O>[C:15]([C:10]1[CH:9]=[C:8]([CH:6]([CH3:7])[CH2:5][OH:4])[CH:13]=[CH:12][C:11]=1[OH:14])(=[O:17])[CH3:16]

참가 물질

5

반응물 2

HCID 516892Sodium BicarbonateHCID 213220012-(3-Acetyl-4-hydroxyphenyl)propyl acetate

생성물 1

HCID 213220152-(3-Acetyl-4-hydroxyphenyl)propan-1-ol수율 72%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

2-(3-Acetyl-4-hydroxyphenyl)propyl acetate (20.0g; 0.0847 mol) and sodium bicarbonate (25.4g; 0.31 mol) were dissolved in ethanol (200 ml) and water (150 ml), and the mixture was refluxed for 20 hours. Ethanol was removed in vacuo and the residue was extracted with ether (3 × 150 ml). The combined ether extracts were washed with water, saturated sodium bicarbonate solution, brine, and then dried over magnesium sulphate. The product, after removing solvent, was chromatographed on silica gel using ether as eluent to give a pale brown oil (15.0g; 72% yield).

후처리

  1. customEthanol was removed in vacuo
  2. extractionthe residue was extracted with ether (3 × 150 ml)
  3. washThe combined ether extracts were washed with water, saturated sodium bicarbonate solution, brine
  4. dry with materialdried over magnesium sulphate
  5. customThe product, after removing solvent
  6. customwas chromatographed on silica gel
  7. customto give a pale brown oil (15.0g; 72% yield)

출처 및 근거

ORD 기록
ord-136bdf3970c64e32858c8a7129b583d6
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04057641

연결된 노트

불러오는 중…