N-Methylanthranilic acid → 9-Methyl-5,6,7,8-tetrahydrocarbazole-1-carboxylic acid

HRID 1438993

반응식

HRID 1438993 반응식
Br[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.[CH3:9][NH:10][C:11]1[C:12](=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:13]([OH:15])=[O:14]>>[CH3:9][N:10]1[C:11]2[C:12]([C:13]([OH:15])=[O:14])=[CH:16][CH:17]=[CH:18][C:19]=2[C:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=2

참가 물질

3

반응물 2

HCID 67069N-Methylanthranilic acidHCID 117897582-Bromocyclohexanone

생성물 1

HCID 213999599-Methyl-5,6,7,8-tetrahydrocarbazole-1-carboxylic acid수율 15%

실험 절차

Under the conditions of Example 59, 2-bromocyclohexanone is reacted with the methyl ester of N-methylanthranilic acid. After recrystallization from methanol, the methyl ester of 9-methyl-5,6,7,8-tetrahydrocarbazole-1-carboxylic acid is obtained in a 15% yield, m.p. 56° C.

후처리

  1. customAfter recrystallization from methanol

출처 및 근거

ORD 기록
ord-931aa3ebb34646b3a5ae4a4ff6fd3ba4
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04057640

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