Thionyl Chloride → 3-(2',4'-Difluoro-4-biphenylyl)butyryl chloride

HRID 1439038노트

반응식

HRID 1439038 반응식
S(Cl)([Cl:3])=O.[F:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[C:13]1[CH:18]=[CH:17][C:16]([CH:19]([CH3:24])[CH2:20][C:21](O)=[O:22])=[CH:15][CH:14]=1>C1C=CC=CC=1>[F:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[C:13]1[CH:18]=[CH:17][C:16]([CH:19]([CH3:24])[CH2:20][C:21]([Cl:3])=[O:22])=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

생성물 1

HCID 213226013-(2',4'-Difluoro-4-biphenylyl)butyryl chloride

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

6 g. of thionyl chloride and 10 g. of 3-(2',4'-difluoro-4-biphenylyl)butyric acid in 80 ml. of benzene are allowed to stand at 25° for 24 hours and the mixture is evaporated under reduced pressure to give 3-(2',4'-difluoro-4-biphenylyl)butyryl chloride.

후처리

  1. customthe mixture is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-8b341343d8a14354badf584bfeaaf01d
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04057647

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