Formic Acid → 1-Formyloxy-3-(2',4'-difluoro-4-biphenylyl)butan-3-ol

반응식

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([OH:20])([CH3:19])[CH2:16][CH2:17][OH:18])=[CH:11][CH:10]=1.[CH:21](O)=[O:22]>>[CH:21]([O:18][CH2:17][CH2:16][C:15]([C:12]1[CH:13]=[CH:14][C:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])=[CH:10][CH:11]=1)([OH:20])[CH3:19])=[O:22]

참가 물질

반응물 2

HCID 284Formic Acid

HCID 213225623-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol

생성물 1

HCID 213225931-Formyloxy-3-(2',4'-difluoro-4-biphenylyl)butan-3-ol

실험 절차

3 g. of 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol and 15 ml. of formic acid are warmed to 80° for 2 hours. The mixture is cooled and worked up in the customary manner to give 1-formyloxy-3-(2',4'-difluoro-4-biphenylyl)butan-3-ol.

후처리

temperatureThe mixture is cooled

출처 및 근거

ORD 기록: ord-262bc829bcd44d36b30429e9cda7c401
출처 데이터셋: uspto-grants-1977_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04057647

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