Acetic Acid → HCID 21398245, 화합물

반응식

[CH3:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:13]=1[OH:14])[CH2:5][CH2:6][C:7]([O:9][CH3:10])=[O:8].[CH2:19]([S:37][CH2:38][CH:39]([OH:42])CO)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36].[CH3:43][O-:44].[Na+].[C:46]([OH:49])(=O)[CH3:47]>>[CH2:19]([S:37][CH2:38][CH:39]([O:42][C:43](=[O:44])[CH2:4][CH2:3][C:2]1[CH:1]=[C:47]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:46]([OH:49])=[C:12]([CH3:11])[CH:13]=1)[CH2:10][O:9][C:7](=[O:8])[CH2:6][CH2:5][C:4]1[CH:11]=[C:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:13]([OH:14])=[C:2]([CH3:1])[CH:3]=1)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36]

참가 물질

반응물 4

HCID 176Acetic Acid

HCID 165455Methyl 3-(1,1-dimethylethyl)-4-hydroxy-5-methylbenzenepropanoate

HCID 2459623-Octadecylsulfanylpropane-1,2-diol

HCID 10942334Sodium Methoxide

생성물 1

HCID 21398245HCID 21398245, 화합물

반응 조건

온도: 80 °C

실험 절차

A mixture of 15.2 grams (0.06 mole) of methyl 3-methyl-5-tert-butyl-4-hydroxyhydrocinnamate and 10.14 grams (0.027 mole) of 1-n-octadecylthio-2,3-propanediol was heated to about 80° C and stirred until the mixture became homogenous. Sodium methylate (0.292 grams, 0.0054 mole) was added, and the resulting mixture was heated at 125°-145° C for 5 hours at atmospheric pressure and another 3 hours at 135°-145° C at 0.5-5 mm. The reaction mixture was then cooled and the catalyst neutralized with 0.5 grams (0.008 mole) of glacial acetic acid. Purification of the crude product was achieved by first removing the bulk (1.0 g) of the unreacted starting ester under high vacuum in a Hickman molecular still, followed by chromatography from silica gel using benzene as the eluting solvent.