2-Benzoylbenzoic Acid → HCID 21398396, 화합물

HRID 1439173노트

반응식

HRID 1439173 반응식
[C:1]([C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([OH:13])=O)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([NH:21][CH2:22][CH2:23][CH2:24][NH2:25])[CH2:19][CH3:20].ClC1C=CC=CC=1Cl>O>[CH2:18]([N:21]1[C:1]2([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:9]3[C:10]([C:11](=[O:13])[N:25]2[CH2:24][CH2:23][CH2:22]1)=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:19][CH3:20]

참가 물질

5

반응물 3

HCID 68132-Benzoylbenzoic AcidHCID 72391,2-DichlorobenzeneHCID 90250N-Propylpropane-1,3-diamine

생성물 1

HCID 21398396HCID 21398396, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

22.6 Parts of o-benzoyl-benzoic acid and 11.6 parts of N-propyl-1,3-propanediamine are haeted within 11/2 hours with 50 parts by volume of o-dichlorobenzene until the boiling point of the latter is attained. Almost the theoretical amount of reaction water is azeotropically distilled off. The clear solution is evaporated to dryness in vacuo, the oily residue is dissolved in ethyl acetate and crystallised by the dropwise addition of pentane. In this way, 1-propyl-10b-phenyl-1,3,4,10b-tetrahydro-pyrimido[2,1-a]isoindol-6(2H)-one is obtained of the formula ##STR19## M.P. 135°-137°. 1-Ethyl-10b-phenyl-1,3,4,10b-tetrahydro-pyrimido[2,1-a]isoindol -6(2H)-one is obtained in the same manner from o-benzoyl-benzoic acid and N-ethyl-1,3-propanediamine. M.P. 131°-133°.

후처리

  1. custom2 hours
  2. distillationis azeotropically distilled off
  3. customThe clear solution is evaporated to dryness in vacuo
  4. dissolutionthe oily residue is dissolved in ethyl acetate
  5. customcrystallised by the dropwise addition of pentane

출처 및 근거

ORD 기록
ord-9ec9e32eb84549c7a900d2c8f12a4ce5
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04058529

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