Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Pentanol → 2-[(4-Methoxyphenyl)amino]benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Pentanol | HCID 6276 | — |
| 반응물 | P-Anisidine | HCID 7732 | — |
| 반응물 | 2-Chlorobenzoic Acid | HCID 8374 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 촉매 | Copper | HCID 23978 | — |
| 생성물 | 2-[(4-Methoxyphenyl)amino]benzoic acid | HCID 202918 | — |
반응 단계
A mixture of 80 g. 2-chlorobenzoic acid, 80 g. 4-anisidine, 80 g. potassium carbonate, 4 g. activated copper powder, and 800 ml. amyl alcohol was heated under reflux with efficient stirring for 4 hours. The amyl alcohol was removed by steam distillation and the remaining aqueous phase was filtered and made neutral by addition of 1:1 concentrated hydrochloric acid-water. The resulting solid (102 g.) was collected by filtration to give after recrystallization from isopropyl alcohol N-(4-methoxyphenyl)anthranilic acid; m.p. 183°-184° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04058532 |
| 출처 데이터셋 | uspto-grants-1977_11 |
| ORD ID | ord-03d0e6779745477c814cfade4e9828fc |
| 출처 메모 | uspto-grants-1977_11 |