Chloroacetonitrile → HCID 20393696, 화합물

HRID 1439213노트

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HRID 1439213 반응식
[C:1]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([Cl:16])[C:10]=1[Cl:17])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:19][C:20]#[N:21].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[C:1]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:19][C:20]#[N:21])=[C:11]([Cl:16])[C:10]=1[Cl:17])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 14009997(2,3-Dichloro-4-hydroxyphenyl)(phenyl)methanone

생성물 1

HCID 20393696HCID 20393696, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 26.70 g. (0.10 mole) of 4-benzoyl-2,3-dichlorophenol, 7.40 g. (0.10 mole) of chloroaceto nitrile, 10.40 g. (0.15 mole) of anhydrous K2CO3 and catalytic amount of KI in 200 ml. of acetone was refluxed overnight. The residue was triturated with ether and the product was collected by filtration and dried to yield 22.80 g. (75%); m.p. 110°-112°. This product was used in the next step without further purification.

후처리

  1. additionA mixture of 26.70 g
  2. customThe residue was triturated with ether
  3. filtrationthe product was collected by filtration
  4. customdried
  5. customto yield 22.80 g
  6. customThis product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-a6cb90a5f50c4dedba1a89701683a8a0
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04058559

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