Methane → HCID 21396807, 화합물

A mixture of 111 g of 3-amino-2-cyano-3-propoxypropene-thioamide in 250 ml of ethanol was heated to reflux. To this stirred mixture was added 20.4 g of 30% hydrogen peroxide, at such a rate as to maintain a uniform rate of reflux. After complete addition, the reaction mixture was heated under reflux for 20 minutes. A quantity of activated charcoal was added to the reaction mixture. The reaction mixture was filtered hot and allowed to cool. The filtrate was poured into 1500 ml of water, and the solid precipitate was collected by filtration. The dried solid was recrystallized from toluene, to give 104.5 g of 5-amino-4-cyano-3-propoxyisothiazole, m.p. 122°-125°.

1. temperaturewas heated to reflux
2. temperatureat such a rate as to maintain a uniform rate
3. temperatureof reflux
4. additionAfter complete addition
5. temperaturethe reaction mixture was heated
6. temperatureunder reflux for 20 minutes
7. filtrationThe reaction mixture was filtered hot
8. temperatureto cool
9. additionThe filtrate was poured into 1500 ml of water
10. filtrationthe solid precipitate was collected by filtration
11. customThe dried solid was recrystallized from toluene

ORD 기록

ord-45ae10aa13c442d1978445655465de9c

출처 데이터셋

uspto-grants-1977_11

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US04059433