Ammonium Chloride → HCID 178422376, 화합물

HRID 1439463노트

반응식

HRID 1439463 반응식
[C:1]([C:3]1[C:4](=[O:14])[O:5][C:6]2[C:11]([C:12]=1[CH3:13])=[CH:10][CH:9]=[CH:8][CH:7]=2)#[N:2].[N-:15]=[N+:16]=[N-:17].[Na+].[Cl-].[NH4+]>CN(C=O)C>[CH3:13][C:12]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5][C:4](=[O:14])[C:3]=1[C:1]1[NH:17][N:16]=[N:15][N:2]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 2311463-Cyano-4-methylcoumarin

생성물 1

HCID 178422376HCID 178422376, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 3-cyano-4-methyl coumarin (7.94 g; 0.043 mole) in cimethylformamide (DMF) (45 ml) was added to a mixture of sodium azide (2.92 g; 0.044 mole) and ammonium chloride (2.36 g; 0.044 mole) and the stirred mixture heated on a steam bath for 24 hours. After removal of the solvent under reduced pressure, water (100 ml) was added and the solid filtered off. Acidification of the filtrate, and further aqueous extracts, afforded the title compound; m.p. (EtOH) 213°-4° C (Found: C, 57.58; H, 3.51; N, 24.41; C11H8N4O2 requires; C, 57.89; H, 3.53; N, 24.55%).

후처리

  1. temperaturethe stirred mixture heated on a steam bath for 24 hours
  2. customAfter removal of the solvent under reduced pressure, water (100 ml)
  3. additionwas added
  4. filtrationthe solid filtered off

출처 및 근거

ORD 기록
ord-0ee7cc680d8a4bf292d524c40ab7193d
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04059704

반응 노트

불러오는 중…