Acetone → Methyl 5-cyanopentanoate

HRID 1439537

반응식

HRID 1439537 반응식
[C:1](#[N:6])[CH2:2][CH2:3][CH:4]=[CH2:5].N1C=CC=CC=1.[CH3:13][OH:14].C[C:16](C)=[O:17]>[C]=O.[CH-]=O.[CH-]=O.[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[Co].[Co+2]>[CH3:13][O:14][C:16](=[O:17])[CH2:5][CH2:4][CH2:3][CH2:2][C:1]#[N:6]

참가 물질

7

반응물 4

HCID 180AcetoneHCID 887MethanolHCID 1049PyridineHCID 116044-Pentenenitrile

생성물 1

HCID 554130Methyl 5-cyanopentanoate수율 75.1%

시약·촉매·용매 2

HCID 25049Dicobalt Octacarbonyl (stabilized with 1-5% Hexane)촉매HCID 178418416HCID 178418416, 화합물용매2회

반응 조건

온도
160 °C

실험 절차

A mixture of 8.1 parts of 4-pentenonitrile, 1.4 parts of dicobalt octacarbonyl, 2.6 parts of pyridine, 8 parts of methanol and 30 parts of acetone is reacted in the same way as in Example 1. The pressure is brought to 200 bars by forcing in carbon monoxide at room temperature. The autoclave is heated to 160° C, the pressure is raised to 300 bars by forcing in further carbon monoxide, and the autoclave is shaken for two hours under these conditions. Fractional distillation of the material discharged from the autoclave gives 10.6 parts of 5-cyanovaleric acid methyl ester (75.1% of theory); boiling point 122°-124° C/11 mm Hg.

후처리

  1. customis reacted in the same way as in Example 1
  2. temperaturethe pressure is raised to 300 bars
  3. distillationFractional distillation of the material

출처 및 근거

ORD 기록
ord-f9c20d1089c1415ba4841aa3e5adb3f6
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04060543

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