Ethylene Oxide → 2-[Benzyl(2-hydroxyethyl)amino]benzamide

HRID 1439612노트

반응식

HRID 1439612 반응식
[CH2:1]([NH:8][C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([NH2:13])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]1[O:20][CH2:19]1>C(O)(=O)C>[CH2:1]([N:8]([CH2:18][CH2:19][OH:20])[C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([NH2:13])=[O:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6354Ethylene OxideHCID 11345158HCID 11345158, 화합물

생성물 1

HCID 203383632-[Benzyl(2-hydroxyethyl)amino]benzamide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

o-Benzylaminobenzamide (62 g) was added to a cold solution of 85 ml ethylene oxide in 500 ml acetic acid, the mixture stirred 22 hours at room temperature and concentrated on the rotovap to remove 250 ml acetic acid. The remainder was made alkaline with 10% NaOH and the solid filtered washed with water and recrystallized from 300 ml ethyl acetate to give 48.5 g. product, m.133-7°.

후처리

  1. concentrationconcentrated on the rotovap
  2. customto remove 250 ml acetic acid
  3. filtrationthe solid filtered
  4. washwashed with water
  5. customrecrystallized from 300 ml ethyl acetate
  6. customto give 48.5 g
  7. custom133-7°

출처 및 근거

ORD 기록
ord-6b167cf4c02242e99b2eb72f8e049521
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04060526

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