Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-6,7-dimethoxy-4-quinazolinamine → 4-Amino-2-[4-(cyclohexylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-6,7-dimethoxy-4-quinazolinamine | HCID 90235 | — |
| 반응물 | 1-(Cyclohexylcarbonyl)piperazine | HCID 3437502 | — |
| 생성물 | 4-Amino-2-[4-(cyclohexylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline | HCID 21183920 | — |
반응 단계
N-(Cyclohexylcarbonyl)piperazine (5.9 g., 0.03 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (7.2 g., 0.03 mole) are reacted according to the procedure of Example 1(a). The crude product crystallized from methanol affords analytically pure 4-amino-2-[4-(cyclohexylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline, m.p. 223°-225° C., resolidifying and remelting at 248.0°-250.0° C. (corr.)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04060615 |
| 출처 데이터셋 | uspto-grants-1977_11 |
| ORD ID | ord-899bd19483c44d4794d555423195de9b |
| 출처 메모 | uspto-grants-1977_11 |