1,4-Dioxaspiro[4.5]decan-8-one → 8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol

HRID 1439884노트

반응식

HRID 1439884 반응식
[CH2:1]1[O:11][C:4]2([CH2:9][CH2:8][C:7](=[O:10])[CH2:6][CH2:5]2)[O:3][CH2:2]1.[F:12][C:13]1[CH:14]=[C:15]([Mg]Br)[CH:16]=[CH:17][C:18]=1[F:19]>>[F:12][C:13]1[CH:14]=[C:15]([C:7]2([OH:10])[CH2:6][CH2:5][C:4]3([O:3][CH2:2][CH2:1][O:11]3)[CH2:9][CH2:8]2)[CH:16]=[CH:17][C:18]=1[F:19]

참가 물질

3

반응물 2

HCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 178505835HCID 178505835, 화합물

생성물 1

HCID 221221048-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol수율 42%

실험 절차

This compound was prepared from 1,4-cyclohexanedione monoethylene ketal (15.6 g, 100 mmole) and 3,4-difluorophenyl magnesium bromide (100 mmole) in the usual mariner. The crude product was crystallized from isopropyl ether to give the product (42%, mp: 118°-120° C.).

후처리

  1. customThe crude product was crystallized from isopropyl ether

출처 및 근거

ORD 기록
ord-968e0b33d582476d8da95924c5380d24
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05496847

반응 노트

불러오는 중…