(1-Phenylcyclopentyl)methanamine → (1-Phenylcyclopentyl)methyl-3-(2,2,6-trimethyl-2,3-dihydrobenzofuran-7-yl)urea

HRID 1439928노트

반응식

HRID 1439928 반응식
[C:1]1([C:7]2([CH2:12][NH2:13])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:14][C:15]1([CH3:28])[CH2:19][C:18]2[CH:20]=[CH:21][C:22]([CH3:27])=[C:23]([N:24]=[C:25]=[O:26])[C:17]=2[O:16]1>C(OCC)(=O)C>[C:1]1([C:7]2([CH2:12][NH:13][C:25]([NH:24][C:23]3[C:17]4[O:16][C:15]([CH3:14])([CH3:28])[CH2:19][C:18]=4[CH:20]=[CH:21][C:22]=3[CH3:27])=[O:26])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 205131(1-Phenylcyclopentyl)methanamineHCID 189850842,2,6-Trimethyl-2,3-dihydrobenzofuran-7-yl isocyanate

생성물 1

HCID 22078692(1-Phenylcyclopentyl)methyl-3-(2,2,6-trimethyl-2,3-dihydrobenzofuran-7-yl)urea

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A 60 mg amount of (1-phenycyclopentyl)methylamine was added to a solution of 70 mg of 2,2,6-trimethyl-2,3-dihydrobenzofuran-7-yl isocyanate in 2 ml of ethyl acetate, and the mixture was stirred at room temperature for 15 hrs. The solvent was removed by evaporation under reduced pressure, and the residue was subjected to recrystallization to provide 65 mg of the intended title compound.

후처리

  1. customThe solvent was removed by evaporation under reduced pressure
  2. customthe residue was subjected to recrystallization

출처 및 근거

ORD 기록
ord-cdba0ed79de547ddb1a2cc12c0538a35
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05496853

반응 노트

불러오는 중…