Ethyl Acetate → 6-O-acetylglucal

HRID 1439987노트

반응식

HRID 1439987 반응식
[O:1]1[C@H:8]([CH2:9][OH:10])[C@@H:6]([OH:7])[C@H:4]([OH:5])[CH:3]=[CH:2]1.[C:11](OCC)(=[O:13])[CH3:12]>C(OC=C)(=O)C>[C:11]([O:10][CH2:9][C@H:8]1[O:1][CH:2]=[CH:3][C@@H:4]([OH:5])[C@@H:6]1[OH:7])(=[O:13])[CH3:12]

참가 물질

4

반응물 2

HCID 8857Ethyl AcetateHCID 2734736D-(+)-Glucal

생성물 1

HCID 100476776-O-acetylglucal수율 85%

시약·촉매·용매 1

HCID 7904Vinyl Acetate용매

실험 절차

1.022 g (7 mmol) of glucal are taken up in 2 ml of ethyl acetate and 30 ml of vinyl acetate, 400 mg of lipase from Candida cylindracea lipase OF (Meito Sangyo Co. Ltd.) are added, and the mixture is stirred at room temperature overnight. After the reusable enzyme has been separated off, and subsequent chromatography or crystallization, 1.12-1.25 g of 6-O-acetylglucal (85-95% yield) are obtained.

후처리

  1. customAfter the reusable enzyme has been separated off

출처 및 근거

ORD 기록
ord-622e017256974e258a44c833953015fa
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05496930

반응 노트

불러오는 중…