Methanol → 1-Methyl-3-n-propyl-2-iminoimidazolidin-4-one

반응식

I.[CH3:2][N:3]1[CH2:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4]1=[NH:12].CO.[OH-].[K+]>>[CH3:2][N:3]1[CH2:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4]1=[NH:12]

참가 물질

반응물 3

HCID 887Methanol

HCID 14797Potassium Hydroxide

HCID 676185061-Methyl-3-n-propyl-2-iminoimidazolidin-4-one hydroiodide

생성물 1

HCID 542389381-Methyl-3-n-propyl-2-iminoimidazolidin-4-one수율 74.7%

실험 절차

2.83 g (10 mmol) of the 1-methyl-3-n-propyl-2-iminoimidazolidin-4-one hydroiodide was added to 25 ml of methanol containing 0.66 g (10 mmol) of 85% potassium hydroxide, and the mixture was stirred at room temperature for one hour. Methanol was distilled off under reduced pressure, and chloroform was added to the residue. Precipitated crystals were removed by filtration. Chloroform was distilled off under reduced pressure to obtain 1.16 g of 1-methyl-3-n-propyl-2 -iminoimidazolidin-4-one as an oily substance.

후처리

distillationMethanol was distilled off under reduced pressure, and chloroform
additionwas added to the residue
customPrecipitated crystals
customwere removed by filtration
distillationChloroform was distilled off under reduced pressure

출처 및 근거

ORD 기록: ord-c08634c764ad4bdbb610fbcbf4502dd7
출처 데이터셋: uspto-grants-1996_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05500406

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