Water → 2,3-Dihydro-5-methoxy-1,4-benzodioxin

HRID 1440818

반응식

HRID 1440818 반응식
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][CH:7]=[C:5]([OH:6])[C:4]=1[OH:10].Br[CH2:12][CH2:13]Br.C(=O)([O-])[O-].[K+].[K+].O>OCC(CO)O.[Cu]>[CH3:1][O:2][C:3]1[C:4]2[O:10][CH2:13][CH2:12][O:6][C:5]=2[CH:7]=[CH:8][CH:9]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 78391,2-DibromoethaneHCID 11430Potassium CarbonateHCID 136223-Methoxycatechol

생성물 1

HCID 743712,3-Dihydro-5-methoxy-1,4-benzodioxin

시약·촉매·용매 2

HCID 23978Copper촉매HCID 753Glycerol용매

반응 조건

온도
110 °C

실험 절차

A heterogeneous mixture containing 1.42 mol of 3-methoxycatechol, 1.57 mol of 1,2-dibromoethane, 1.42 mol of potassium carbonate and 4 g of copper powder in 150 ml of glycerol is heated at 110° C. for 15 hours. After cooling, the mixture is poured into 1 l of water. The aqueous phase is extracted with ethyl ether. The ether phases are then washed with 1N sodium hydroxide, dried and evaporated, and give the expected product.

후처리

  1. temperatureAfter cooling
  2. extractionThe aqueous phase is extracted with ethyl ether
  3. washThe ether phases are then washed with 1N sodium hydroxide
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-3e0e7df9f5d944b48480b7e0c5e1eedc
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05500443

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