Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Fmoc-Gly-OH → L-Aspartic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Fmoc-Gly-OH | HCID 93124 | — |
| 반응물 | Fmoc-L-tryptophan | HCID 978343 | — |
| 반응물 | (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid | HCID 978356 | — |
| 반응물 | Fmoc-Lys(Boc)-OH | HCID 2724628 | — |
| 반응물 | Fmoc-L-Asp(OtBu)-OH | HCID 2724635 | — |
| 반응물 | (2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid | HCID 7009636 | — |
| 생성물 | L-Aspartic Acid | HCID 5960 | — |
| 생성물 | L-Phenylalanine | HCID 6140 | — |
| 생성물 | L-Tryptophan | HCID 6305 | — |
| 생성물 | N-Methylphenylalanine | HCID 6951135 | — |
반응 단계
Following the procedure of Table 2, Fmoc-MePhe-OH, Fmoc-Asp(OtBu)-OH, Fmoc-Ahx-OH, Fmoc-Trp-OH, Fmoc-Gly-OH, Fmoc-Lys(Boc)-OH and Hpa-OSu were sequentially coupled to the Rink amide resin. Following removal of the peptide from the resin using standard procedures the 2-methylphenylacetamide group was added to the ε-amino of Lys using o-tolylisocyanate. Amino Acid analysis following acid decomposition gave Asp 1.01 (1), Gly 1.03 (1), MePhe 0.98 (1), Lys 0.94 (1), Ahx 1.04 (1), Trp 0.96 (1). MS (FAB): m/e 1046 (M-H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05502164 |
| 출처 데이터셋 | uspto-grants-1996_03 |
| ORD ID | ord-889b22e9d42f406aa9988298f046f9c0 |
| 출처 메모 | uspto-grants-1996_03 |