Ammonia → 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol

HRID 1441309노트

반응식

HRID 1441309 반응식
C([O:4][CH2:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:35]=[CH:34][C:17]([NH:18][C:19]3[N:24]=[C:23]([C:25]4[N:29]([CH:30]([CH3:32])[CH3:31])[C:28]([CH3:33])=[N:27][CH:26]=4)[CH:22]=[CH:21][N:20]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])(=O)C.N>CO>[OH:4][CH2:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:35]=[CH:34][C:17]([NH:18][C:19]3[N:24]=[C:23]([C:25]4[N:29]([CH:30]([CH3:32])[CH3:31])[C:28]([CH3:33])=[N:27][CH:26]=4)[CH:22]=[CH:21][N:20]=3)=[CH:16][CH:15]=2)[CH2:12][CH2:13]1)=[O:7]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 686898132-{4-[4-(2-Acetoxyacetyl)piperazin-1-yl]anilino}-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidine

생성물 1

HCID 112705002-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

2-{4-[4-(2-Acetoxyacetyl)piperazin-1-yl]anilino}-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidine (Example 21; 330 mg) was stirred in MeOH (5 ml) at room temperature and 7N ammonia in MeOH (1.6 ml) was added. After 28 hours, the reaction was evaporated under reduced pressure. Chromatography on silica gel using MeOH:DCM (4:96 to 5:95), yielded the title compound as a yellow solid. (108 mg 36%). NMR: 1.39 (d, 6H), 2.46 (s, 3H), 3.05 (b s, 4H), 3.48 (b s, 2H), 3.61 (b s, 2H), 4.12 (d, 2H), 4.57 (t, 1H), 5.69 (septuplet, 1H), 6.92 (d, 2H), 6.95 (d, 1H), 7.38 (s, 1H), 7.47 (d, 2H), 8.31 (d, 1H), 9.15 (s, 1H); m/z 436.

후처리

  1. customthe reaction was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-7a3c34f467ef486aac1c149bd7c1d186
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07655652B2

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