Acetyl chloride → (2R,5S)-1-Acetyl-2,5-dimethyl-4-(4-nitrophenyl)piperazine

HRID 1441360노트

반응식

HRID 1441360 반응식
[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1.[C:18](Cl)(=[O:20])[CH3:19]>>[C:18]([N:6]1[CH2:7][C@H:2]([CH3:1])[N:3]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)[CH2:4][C@H:5]1[CH3:8])(=[O:20])[CH3:19]

참가 물질

3

반응물 2

HCID 6367Acetyl chlorideHCID 57664370(2S,5R)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine

생성물 1

HCID 68686760(2R,5S)-1-Acetyl-2,5-dimethyl-4-(4-nitrophenyl)piperazine

실험 절차

The title compound was prepared from (2S,5R)-2,5-dimethyl-1-(4-nitrophenyl)piperazine (Method 28, 8.22 g, 34.95 mmol) and acetyl chloride (4.5 ml, 62.91) by the procedure of Method 26. It was obtained as an oil which solidified on standing overnight (11.39 g, >100%, contaminated with solvent) NMR (400 MHz) 1.13 (m, 6H), 3.07 (m, 1H), 3.33 (m, 1H), 3.68 (m, 1H), 4.25 (m, 2H), 4.69 (m, 1H), 7.00 (d, 2H), 8.05 (d, 2H); m/z 278.

후처리

  1. customIt was obtained as an oil which

출처 및 근거

ORD 기록
ord-9c492de619204a849626a739f798695f
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07655652B2

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