Trifluoroacetic acid → 4-(2-Aminoethyl)benzonitrile

HRID 1441686노트

반응식

HRID 1441686 반응식
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=1)(C)(C)C.FC(F)(F)C(O)=O.C(OCC)(=O)C>ClCCl>[NH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 21955533tert-Butyl 4-cyanophenethylcarbamate

생성물 1

HCID 219125254-(2-Aminoethyl)benzonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1.90 g commercially available [2-(4-Cyano-phenyl)-ethyl]-carbamic acid tert-butyl ester were dissolved in 100 ml dichloromethane. 10 ml trifluoroacetic acid were added and the reaction mixture was stirred at room temperature for one hour. 250 ml ethyl acetate were added and the mixture was washed three times with saturated NaHCO3 solution. The organic layer was dried over MgSO4 and then the solvent was removed in vacuo to obtain 700 mg 4-(2-Amino-ethyl)-benzonitrile as pale yellow solid.

후처리

  1. washthe mixture was washed three times with saturated NaHCO3 solution
  2. dry with materialThe organic layer was dried over MgSO4
  3. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-1f50f452ad114a5f9558744c8ad85374
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07655679B2

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