HCID 21874993, 화합물 → 5-Amino-3-bromo-2-pyridinecarbonitrile

HRID 1441856노트

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HRID 1441856 반응식
[Br:1][C:2]1[C:3]([C:11]#[N:12])=[N:4][CH:5]=[C:6]([N+:8]([O-])=O)[CH:7]=1>[Fe].CCOCC>[NH2:8][C:6]1[CH:7]=[C:2]([Br:1])[C:3]([C:11]#[N:12])=[N:4][CH:5]=1

참가 물질

4

반응물 1

HCID 21874993HCID 21874993, 화합물

생성물 1

HCID 218752405-Amino-3-bromo-2-pyridinecarbonitrile

시약·촉매·용매 2

HCID 23925Iron촉매HCID 3283Diethyl Ether용매

실험 절차

3-Bromo-2-cyano-5-nitropyridine (0.4 g, 1.75 mmol) and iron powder (0.51 g, 8.8 mmol, 325 Mesh) were reacted as described in example 762D. The crude solid obtained by trituration with ether was purified by SiO2 Prep-TLC using 4:1 CH2Cl2/ether as eluent to give compound 769A (0.16 g, (65%) as an off-white solid. HPLC: 100% at 1.77 min(YMC S5 ODS column) eluting with 10-90% aqueous methanol containing 0.2% phosphoric acid over a 4 min gradient monitoring at 220 nm. MS (ES): m/z 197.93 [M+H]+.

후처리

  1. customwas purified by SiO2 Prep-TLC

출처 및 근거

ORD 기록
ord-fcd2257e991e497b96f66790d3d8a7e5
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07655689B2

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