참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylenediamine | HCID 3301 | — |
| 반응물 | 2-Amino-5-bromo-4-methylpyridine | HCID 817695 | — |
| 반응물 | HCID 178418546 | HCID 178418546 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 6-Amino-4-methylnicotinonitrile | HCID 9964103 | 87% |
반응 단계
A mixture of 5-bromo-4-methyl-pyridin-2-ylamine (500 mg, 2.67 mmol), CuCN (478 mg, 5.34 mmol) and DMA (2 mL) was stirred under nitrogen for 20 h at 170° C. The reaction mixture was cooled and added to 50 mL of a 20% aqueous solution of ethane-1,2-diamine. The layers were separated and the aqueous layer was extracted 3× with EtOAc. The combined organics were washed with water followed by brine and dried over MgSO4. Concentration in vacuo afforded compound 851A (309 mg, 87%) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07655689B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_02 |
|---|
| ORD ID | ord-f1cda6e7b855453aba081b91d743fa7d |
|---|
| 출처 메모 | uspto-grants-2010_02 |
|---|
