2,3,5-Trifluorobenzaldehyde → 2-[Bis(cyclopropylmethyl)amino]-3,5-difluorobenzaldehyde

HRID 1442523노트

반응식

HRID 1442523 반응식
F[C:2]1[C:9]([F:10])=[CH:8][C:7]([F:11])=[CH:6][C:3]=1[CH:4]=[O:5].[CH:12]1([CH2:15][NH:16][CH2:17][CH:18]2[CH2:20][CH2:19]2)[CH2:14][CH2:13]1.C1(CNCC)CCCC1>>[CH:12]1([CH2:15][N:16]([CH2:17][CH:18]2[CH2:20][CH2:19]2)[C:2]2[C:9]([F:10])=[CH:8][C:7]([F:11])=[CH:6][C:3]=2[CH:4]=[O:5])[CH2:14][CH2:13]1

참가 물질

4

반응물 3

HCID 27769502,3,5-TrifluorobenzaldehydeHCID 15284719Bis(cyclopropylmethyl)amineHCID 43163716N-(cyclopentylmethyl)-N-ethylamine

생성물 1

HCID 866289772-[Bis(cyclopropylmethyl)amino]-3,5-difluorobenzaldehyde

실험 절차

By using 2,3,5-trifluorobenzaldehyde instead of 2-fluoro-5-(trifluoromethyl)benzaldehyde, and N,N-bis(cyclopropylmethyl)amine synthesized by the method described in International Patent Publication WO2006/073973 instead of N-(cyclopentylmethyl)-N-ethylamine, reactions and treatments were performed in the same manner as those of Step 3 of Example 1 to obtain 2-[bis(cyclopropylmethyl)amino]-3,5-difluorobenzaldehyde as a yellow oil.

후처리

  1. customsynthesized by the method

출처 및 근거

ORD 기록
ord-1c44551e5365410ba8aadd71b3bf484e
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07659271B2

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