HCID 22185398, 화합물 → HCID 22185405, 화합물

HRID 1442651노트

반응식

HRID 1442651 반응식
[CH3:1][O:2][C:3]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:4]=1[O:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[H][H]>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3]1[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:4]=1[O:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

참가 물질

5

반응물 2

HCID 22185398HCID 22185398, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 22185405HCID 22185405, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 10% Pd/C (0.25 g) was added to a solution of 4-[2-(2-methoxy-4-nitro-phenoxy)-ethyl]-morpholine Compound 42a3 (1.4 g, 5.0 mmol) in EtOAc (50 mL). The solution was exposed to 40 PSI of hydrogen gas for a period of 1 hr. The catalyst was removed by filtration through Celite 545 and the solvent was removed to give 3-methoxy-4-(2-morpholin-4-yl-ethoxy)-phenylamine Compound 42a (1.1 g). MS 253 (MH+).

후처리

  1. customThe catalyst was removed by filtration through Celite 545
  2. customthe solvent was removed

출처 및 근거

ORD 기록
ord-286890e9bbaf4481b916e52e78d4eafd
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07659284B2

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