Thionyl Chloride → 2-(4-Chloromethyl-phenyl)-2h-[1,2,3]triazole

HRID 1442676노트

반응식

HRID 1442676 반응식
[N:1]1[N:2]([C:6]2[CH:11]=[CH:10][C:9]([CH2:12]O)=[CH:8][CH:7]=2)[N:3]=[CH:4][CH:5]=1.S(Cl)([Cl:16])=O.C([O-])(O)=O.[Na+]>C(Cl)Cl>[Cl:16][CH2:12][C:9]1[CH:10]=[CH:11][C:6]([N:2]2[N:3]=[CH:4][CH:5]=[N:1]2)=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 21943696(4-[1,2,3]Triazol-2-yl-phenyl)-methanol

생성물 1

HCID 219436922-(4-Chloromethyl-phenyl)-2h-[1,2,3]triazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 50.58 g (289 mmol) of (4-[1,2,3]triazol-2-yl-phenyl)-methanol in 2000 ml of CH2Cl2, 31.59 ml (433 mmol) of thionyl chloride Is added dropwise at 0-5° C. and the reaction mixture is allowed to warm to r.t. After stirring for 16 h, the reaction mixture is basified with sat. NaHCO3 at 0-5° C. and extracted with CH2Cl2. The combined extracts are washed with brine, dried over MgSO4 and concentrated under reduced pressure to provide the title compound.

후처리

  1. extractionextracted with CH2Cl2
  2. washThe combined extracts are washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4604988c861542f2a119534721babbf4
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07659293B2

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