Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1442749생성일: 2026년 10월 24일
Dimethylformamide → 4-(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-2-yl)benzene-1-sulfonyl chloride
https://huagongshe.com/ko/reaction/1442749
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 4-(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-2-yl)benzenesulfonic acid | HCID 59166308 | — |
| 용매 | Phosphorus oxychloride | HCID 24813 | — |
| 생성물 | 4-(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-2-yl)benzene-1-sulfonyl chloride | HCID 59166108 | — |
반응 단계
4-(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-2-yl)benzenesulfonic acid (1.9 g, 4.3 mmol) was dissolved in POCl3 (30 mL) followed by the addition of SOCl2 (3 mL) and DMF (100 μl). The reaction mixture was heated at 70-80° C. for 15 min. The volatiles were evaporated and then re-evaporated with chloroform-toluene. The residual brown oil was diluted with chloroform (22 mL) and used for sulfonylation immediately. ESI-MS m/z calc. 456.0, found 457.1 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07659268B2 |
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| 출처 데이터셋 | uspto-grants-2010_02 |
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| ORD ID | ord-669114f9c82b4711b09b91bf3c9cc057 |
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| 출처 메모 | uspto-grants-2010_02 |
|---|
