Methyl 3-methyl-1-oxidopyridin-4-yl ether → 4-Methoxy-3-methylpyridine

HRID 1442893노트

반응식

HRID 1442893 반응식
[CH3:1][C:2]1[CH:3]=[N+:4]([O-])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]>[Pd].CO>[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

참가 물질

4

반응물 1

HCID 817250Methyl 3-methyl-1-oxidopyridin-4-yl ether

생성물 1

HCID 47377664-Methoxy-3-methylpyridine수율 90.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 4 g (28.8 mmol) 3-methyl-4-methoxy pyridine N-oxide (prepared according to the method described in Kohl, Bernhard et al; J. Med. Chem.; 1992; 1049-1057) and 1.1 mg of 5% palladium on charcoal in 50 ml of methanol is hydrogenated at 20 atms at room temperature for 12 hours (2*6 hours). Filtration through celite, and evaporation gave 3.2 g (90%) of a light green oil.

후처리

  1. customprepared
  2. custom(2*6 hours)
  3. filtrationFiltration
  4. customthrough celite, and evaporation

출처 및 근거

ORD 기록
ord-58e9572b4857474babdd03919fd7ae43
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07659307B2

반응 노트

불러오는 중…