Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 5-Amino-1,2-dihydroquinolin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 5-Nitro-1,2-dihydroquinolin-2-one | HCID 243776 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-Amino-1,2-dihydroquinolin-2-one | HCID 15719078 | 100.3% |
반응 단계
4.5 g of 5-nitroquinolin-2(1H)-one (Chem. Pharm. Bull. 29, 651 (1981)) is hydrogenated in 200 ml of ethyl acetate and 500 ml of methanol in the presence of 450 mg of palladium on activated carbon as a catalyst under normal pressure with hydrogen until the reaction is completed. The catalyst is removed by filtration through diatomaceous earth, and the reaction solution is concentrated by evaporation in a vacuum. 3.8 g of the title compound is obtained as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07659297B2 |
| 출처 데이터셋 | uspto-grants-2010_02 |
| ORD ID | ord-8b5da9200c824d17bcaba8939576762e |
| 출처 메모 | uspto-grants-2010_02 |