Cyclopropanesulfonamide → Cyclopropanesulfonic acid {17-[7-methoxy-8-methyl-2-(6-methyl-pyridin-2-yl)-quinazolin-4-yloxy]-13-methyl-2,14-dioxo-3,13,15-triazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl}-amide

HRID 1443474노트

반응식

[CH3:1][O:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([C:7]([O:21][CH:22]3[CH2:39][CH:38]4[N:24]([C:25](=[O:45])[N:26]([CH3:44])[CH2:27][CH2:28][CH2:29][CH2:30][CH:31]=[CH:32][CH:33]5[C:35]([C:41](O)=[O:42])([NH:36][C:37]4=[O:40])[CH2:34]5)[CH2:23]3)=[N:8][C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[N:15]=3)=[N:10]2)=[CH:5][CH:4]=1.[CH:46]1([S:49]([NH2:52])(=[O:51])=[O:50])[CH2:48][CH2:47]1>>[CH3:1][O:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([C:7]([O:21][CH:22]3[CH2:39][CH:38]4[N:24]([C:25](=[O:45])[N:26]([CH3:44])[CH2:27][CH2:28][CH2:29][CH2:30][CH:31]=[CH:32][CH:33]5[C:35]([C:41]([NH:52][S:49]([CH:46]6[CH2:48][CH2:47]6)(=[O:51])=[O:50])=[O:42])([NH:36][C:37]4=[O:40])[CH2:34]5)[CH2:23]3)=[N:8][C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[N:15]=3)=[N:10]2)=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 15765418Cyclopropanesulfonamide

HCID 6842448917-[7-Methoxy-8-methyl-2-(6-methyl-pyridin-2-yl)-quinazolin-4-yloxy]-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid

생성물 1

HCID 75290662Cyclopropanesulfonic acid {17-[7-methoxy-8-methyl-2-(6-methyl-pyridin-2-yl)-quinazolin-4-yloxy]-13-methyl-2,14-dioxo-3,13,15-triazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl}-amide수율 22.6%

실험 절차

Compound 118 (50 mg, 0.08 mmol) was reacted with cyclopropanesulfonic acid amide (44 mg, 0.36 mmol) according to the procedure described in Example 53 which gave the title compound (13 mg, 22%). MS (M−H)+ 718.2

출처 및 근거

ORD 기록: ord-663fb556de6247279473b72d4e3bb84f
출처 데이터셋: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07659245B2

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