HCID 178439403, 화합물 → CID 57687148

HRID 1443491노트

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HRID 1443491 반응식
Cl[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[C:5]([CH3:15])[C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1.[CH:16]([C:19]1[CH:23]=[CH:22][NH:21][N:20]=1)([CH3:18])[CH3:17]>>[OH:12][C:10]1[C:9]2[C:4](=[C:5]([CH3:15])[C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=[C:2]([N:21]2[CH:22]=[CH:23][C:19]([CH:16]([CH3:18])[CH3:17])=[N:20]2)[N:11]=1

참가 물질

3

반응물 2

HCID 178439403HCID 178439403, 화합물HCID 1784877522-chloro-7-methoxy-8-methyl-1H-quinazolin-4-one

생성물 1

HCID 178487760CID 57687148수율 63.4%

반응 조건

온도
155 °C

실험 절차

A mixture of 2-chloro-4-hydroxy-7-methoxy-8-methylquinazoline (140) (502 mg, 2.23 mmol) and 3-isopropylpyrazole (500 mg, 4.55 mmol) was heated at 155° C. for 10 min. Then, the reaction mixture was successively cooled down to room temperature, partitioned between CH2Cl2 and water, dried (Na2SO4) and evaporated. The residue was triturated in ether and filtered to give the title compound (422 mg, 63%) as white needles: m/z=299 (M+H)+.

후처리

  1. temperatureThen, the reaction mixture was successively cooled down to room temperature
  2. custompartitioned between CH2Cl2 and water
  3. dry with materialdried (Na2SO4)
  4. customevaporated
  5. customThe residue was triturated in ether
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-bbfde6ba36554b468815b89bebe5adab
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07659245B2

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