1-Benzyl-3-trimethylsilyloxy-azetidine → 1-benzylazetidin-3-ol

HRID 1443762노트

반응식

HRID 1443762 반응식
[CH2:1]([N:8]1[CH2:11][CH:10]([O:12][Si](C)(C)C)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[Na+]>CO>[CH2:1]([N:8]1[CH2:11][CH:10]([OH:12])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 38004681-Benzyl-3-trimethylsilyloxy-azetidineHCID 10942334Sodium Methoxide

생성물 1

HCID 38013451-benzylazetidin-3-ol수율 77.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-Benzyl-3-trimethylsilyloxy-azetidine (1.8 g, 7.65 mmol) prepared in preparation example 25 was dissolved in methanol (9 ml), sodium methoxide (826 mg, 15.29 mmol) was added thereto, and stirred at room temperature for 30 min. The solvent was removed by evaporation under a reduced pressure, and the residue was extracted using ethyl acetate. The organic extract layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under a reduced pressure, to obtain 0.964 g (yield: 77%) of the title compound.

후처리

  1. customThe solvent was removed by evaporation under a reduced pressure
  2. extractionthe residue was extracted
  3. washThe organic extract layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-99fdf6ae5f874c87a8fd53e869c2f953
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662810B2

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