HCID 178492049, 화합물 → HCID 43270961, 화합물

HRID 1443838노트

반응식

HRID 1443838 반응식
CN(C)CC[N:5](C)[C:6]1[CH:7]=[C:8]([N:14]2[C:18](S)=NN=[C:15]2[C:20]2C=C(C(C)C)C(O)=C[C:21]=2O)[CH:9]=[CH:10][C:11]=1OC>CO.CCOC(C)=O.[Pd]>[CH3:18][N:14]([CH2:15][CH2:20][CH3:21])[C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([NH2:5])[CH:7]=1

참가 물질

4

반응물 1

HCID 178492049HCID 178492049, 화합물

생성물 1

HCID 43270961HCID 43270961, 화합물수율 116.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21584119Ethylacetate methanol용매

실험 절차

A solution of 9.0 g (40.1 mmol mmol) of (2-Methoxy-5-nitro-phenyl)-methyl-propyl-amine (4) in 200 mL of MeOH/EtOAc (1:1) containing 5% w/w of Pd—C (10%) was subjected to hydrogenation (1 atm, balloon) overnight. The contents of the flask were passed through a short pad of celite and washed with EtOAc. The filtrate was evaporated under reduced pressure to give 7.7 g (92%) of crude amine 4-Methoxy-N3-methyl-N3-propyl-benzene-1,3-diamine (5) of an oil.

후처리

  1. customwas subjected to hydrogenation (1 atm, balloon) overnight
  2. washwashed with EtOAc
  3. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-6283c08881984f199431bcfb50387acd
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662813B2

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