Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → N-[5-(2,3-Dichlorophenylsulphonylamino)-6-methoxy-2-pyrazinyl]-2-hydroxyacetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Hydroxyacetamide | HCID 69021 | — |
| 반응물 | 2,3-dichloro-N-(5-chloro-3-methoxy-2-pyrazinyl)-N-({2-[(trimethylsilyl)oxy]ethoxy}methyl)benzenesulphonamide | HCID 86602800 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-[5-(2,3-Dichlorophenylsulphonylamino)-6-methoxy-2-pyrazinyl]-2-hydroxyacetamide | HCID 59168148 | — |
반응 단계
Procedure as for Example 115 using 2,3-dichloro-N-(5-chloro-3-methoxy-2-pyrazinyl)-N-({2-[(trimethylsilyl)oxy]ethoxy}methyl)benzenesulphonamide (Example 115a) (0.25 g), glycolamide (0.066 g) and sodium hydride (0.035 g of a 60% dispersion in oil) in N,N-dimethylformamide (5 mL). Yield 0.075 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07662825B2 |
| 출처 데이터셋 | uspto-grants-2010_02 |
| ORD ID | ord-faa5e6a36b584441ac2f4a5d723c053b |
| 출처 메모 | uspto-grants-2010_02 |