3-Aminocinnamic acid ethyl ester → 3-(3-{[5-(4-Fluoro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester

HRID 1444277

반응식

HRID 1444277 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:16]([O:18][C:19](=[O:29])[CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([NH2:28])[CH:23]=1)[CH3:17]>>[CH2:16]([O:18][C:19](=[O:29])[CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][C:13]([C:11]2[O:12][C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[CH:9][CH:10]=2)=[O:15])[CH:23]=1)[CH3:17]

참가 물질

3

반응물 2

HCID 978253-Aminocinnamic acid ethyl esterHCID 7389915-(4-Fluorophenyl)furan-2-carboxylic acid

생성물 1

HCID 684973493-(3-{[5-(4-Fluoro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester

실험 절차

5-(4-Fluoro-phenyl)-furan-2-carboxylic acid (54 mg, 0.26 mmol) was coupled to ethyl ester (60) (50 mg, 0.26 mmol) using Method C. The crude residue was purified by column chromatography eluting with 10% EtOAc in heptane to give the title compound.

후처리

  1. customThe crude residue was purified by column chromatography
  2. washeluting with 10% EtOAc in heptane

출처 및 근거

ORD 기록
ord-2d93fd4667ee45978646eacc26cc38ce
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662839B2

연결된 노트

불러오는 중…