5-Bromo-2-fluorobenzoic acid → 3-[3-(5-Bromo-2-fluoro-benzoylamino)-phenyl]-acrylic acid ethyl ester

반응식

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[CH2:12]([O:14][C:15](=[O:33])[CH:16]=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([NH:24]C(C2OC(Br)=CC=2)=O)[CH:19]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:33])[CH:16]=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([NH:24][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=2[F:11])[CH:19]=1)[CH3:13]

참가 물질

반응물 2

HCID 27363155-Bromo-2-fluorobenzoic acid

HCID 684945603-{3-[(5-Bromo-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester

생성물 1

HCID 684970723-[3-(5-Bromo-2-fluoro-benzoylamino)-phenyl]-acrylic acid ethyl ester

실험 절차

5-Bromo-2-fluorobenzoic acid (330 mg, 1.5 mmol) was coupled to aniline (99) (290 mg, 1.5 mmol) using Method C to give the title compound.

출처 및 근거

ORD 기록: ord-490b3f7f40f144af84f7cb639b103c8e
출처 데이터셋: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07662839B2

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