Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 2-(3-aminophenoxy)acetate → [3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 2-(3-aminophenoxy)acetate | HCID 412308 | — |
| 반응물 | 5-Bromo-2-fluorobenzoic acid | HCID 2736315 | — |
| 생성물 | [3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester | HCID 40356283 | — |
반응 단계
5-Bromo-2-fluoro-benzoic acid (250 mg, 1.14 mmol) was coupled to aniline (64) (245 mg, 1.25 mmol) using Method D. The residue was purified by column chromatography eluting with a stepped gradient of 10-15% EtOAc in heptane to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07662839B2 |
| 출처 데이터셋 | uspto-grants-2010_02 |
| ORD ID | ord-e3c279bba8bf4698a6ae01d108be464f |
| 출처 메모 | uspto-grants-2010_02 |