Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(3-Chlorophenyl)boronic acid → {3-[(3'-Chloro-4-fluoro-biphenyl-3-carbonyl)-amino]-phenoxy}-acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (3-Chlorophenyl)boronic acid | HCID 2734323 | — |
| 반응물 | [3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester | HCID 40356283 | — |
| 생성물 | {3-[(3'-Chloro-4-fluoro-biphenyl-3-carbonyl)-amino]-phenoxy}-acetic acid | HCID 59654666 | — |
반응 단계
The phenyl bromide (139) (50 mg, 0.13 mmol) was coupled to 3-chloro-phenylboronic acid (20 mg, 0.13 mmol) using Method E. During this reaction, hydrolysis occurred and the residue was extracted using Work-up E1. The crude product was then triturated with TBME (2 ml), DCM (2 ml), and recrystallised from a hot 10% EtOH in H2O mixture to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07662839B2 |
| 출처 데이터셋 | uspto-grants-2010_02 |
| ORD ID | ord-9fd3aaf315dd455cbdfb1c0024a0f5b9 |
| 출처 메모 | uspto-grants-2010_02 |