3-Fluorophenylboronic acid → (3-[(4,3'-Difluoro-biphenyl-3-carbonyl)-amino]-phenoxy}-acetic Acid Ethyl Ester

HRID 1444376

반응식

HRID 1444376 반응식
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14](=[O:23])[C:15]2[CH:20]=[C:19](Br)[CH:18]=[CH:17][C:16]=2[F:22])[CH:8]=1)[CH3:2].[F:25][C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([C:15]2[CH:20]=[C:19]([C:30]3[CH:29]=[CH:28][CH:27]=[C:26]([F:25])[CH:31]=3)[CH:18]=[CH:17][C:16]=2[F:22])=[O:23])[CH:8]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 27339863-Fluorophenylboronic acidHCID 40356283[3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester

생성물 1

HCID 59654725(3-[(4,3'-Difluoro-biphenyl-3-carbonyl)-amino]-phenoxy}-acetic Acid Ethyl Ester

실험 절차

The phenyl bromide (139) (100 mg, 0.25 mmol) was coupled to 3-fluoro-phenylboronic acid (34 mg, 0.24 mmol) using Method E. During this reaction, partial hydrolysis occurred. The residue was extracted using Work-up E1 to give a mixture of acid and ester, which was used without further purification.

후처리

  1. customDuring this reaction, partial hydrolysis
  2. extractionThe residue was extracted
  3. customto give
  4. customwas used without further purification

출처 및 근거

ORD 기록
ord-8844c3f3d732400b8926495427e5bad2
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662839B2

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