3-Aminocinnamic acid ethyl ester → 3-{3-[(6-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester

HRID 1444379노트

반응식

HRID 1444379 반응식
[CH2:1]([O:3][C:4](=[O:14])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH2:13])[CH:8]=1)[CH3:2].[Br:15][C:16]1[N:21]=[C:20]([C:22](O)=[O:23])[CH:19]=[CH:18][CH:17]=1>>[CH2:1]([O:3][C:4](=[O:14])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:22]([C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([Br:15])[N:21]=2)=[O:23])[CH:8]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 978253-Aminocinnamic acid ethyl esterHCID 5939196-Bromopyridine-2-carboxylic acid

생성물 1

HCID 723488093-{3-[(6-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester

실험 절차

Aniline (60) (124 mg, 0.6 mmol) was coupled to 6-bromo-pyridine-2-carboxylic acid (131 mg, 0.6 mmol) using Method C. The residue was purified by column chromatography eluting in 10% EtOAc in heptane to give the title compound.

후처리

  1. customThe residue was purified by column chromatography
  2. washeluting in 10% EtOAc in heptane

출처 및 근거

ORD 기록
ord-745e3c14140d4d2fa570604c49fd903e
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662839B2

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