Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Amino-1,2-dihydroquinolin-2-one → 5-{[4,4-Dimethyl-6-fluoro-2-hydroxy-5-methoxy-2-trifluoromethyl-1,2,3,4-tetrahydronaphthalen-1-yl]amino}-quinolin-2(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Amino-1,2-dihydroquinolin-2-one | HCID 15719078 | — |
| 반응물 | 4-(3-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal | HCID 17989086 | — |
| 촉매 | Titanium Tetrachloride | HCID 24193 | — |
| 생성물 | 5-{[4,4-Dimethyl-6-fluoro-2-hydroxy-5-methoxy-2-trifluoromethyl-1,2,3,4-tetrahydronaphthalen-1-yl]amino}-quinolin-2(1H)-one | HCID 68680484 | 2.7% |
반응 단계
Analogously to Example 3, the corresponding imine is produced starting from 500 mg of 4-(3-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanal and 260 mg of 5-aminoquinolin-2(1H)-one. By reaction of 80 mg of the imine with 0.5 ml of titanium tetrachloride (1 M in dichloromethane), 20 mg of the title compound is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07662821B2 |
| 출처 데이터셋 | uspto-grants-2010_02 |
| ORD ID | ord-2f0be2b08f894078942d03331164cb12 |
| 출처 메모 | uspto-grants-2010_02 |