Boron tribromide → 5-{[6-Fluoro-2 5-dihydroxy-4,4-dimethyl-2-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-1-yl]amino}-2-methylphthalazin-1-one
반응식
[F:1][C:2]1[C:3]([O:32]C)=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]([NH:12][C:13]1[CH:22]=[CH:21][CH:20]=[C:19]3[C:14]=1[CH:15]=[N:16][N:17]([CH3:24])[C:18]3=[O:23])[C:7]([OH:29])([C:25]([F:28])([F:27])[F:26])[CH2:6][C:5]2([CH3:31])[CH3:30].B(Br)(Br)Br>>[F:1][C:2]1[C:3]([OH:32])=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]([NH:12][C:13]1[CH:22]=[CH:21][CH:20]=[C:19]3[C:14]=1[CH:15]=[N:16][N:17]([CH3:24])[C:18]3=[O:23])[C:7]([OH:29])([C:25]([F:28])([F:26])[F:27])[CH2:6][C:5]2([CH3:30])[CH3:31]참가 물질
3
반응물 2
생성물 1
실험 절차
29 mg of the compound of Example 69 is reacted analogously to Example 1 with 0.13 ml of BBr3 (1N in dichloromethane) to form 18 mg of the title compound.