Methanol → 5-Methyl-1H-indazol-4-amine

HRID 1444489노트

반응식

HRID 1444489 반응식
Cl[C:2]1[C:3]([NH2:11])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[CH3:12]O>[Pd]>[CH3:12][C:2]1[C:3]([NH2:11])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2

참가 물질

4

반응물 2

HCID 887MethanolHCID 179892615-Chloro-1H-indazol-4-amine

생성물 1

HCID 193544325-Methyl-1H-indazol-4-amine수율 6%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

Analogously to the production of 5-chloro-1H-indazol-4-ylamine, the regioisomeric mixture of the previous reaction (1.0 g, 5.64 mmol)) is reacted with 100 mg of palladium on carbon in methanol under hydrogen atmosphere for 16 hours at room temperature. After purification on silica gel with hexane/ethyl acetate (33% hexane, then 100% ethyl acetate), 53 mg (6% of theory) of 5-methyl-1H-indazol-4-ylamine is obtained.

후처리

  1. customAfter purification on silica gel with hexane/ethyl acetate (33% hexane

출처 및 근거

ORD 기록
ord-43cf5a9724da49eaa5e549d6f9a778c6
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662821B2

반응 노트

불러오는 중…